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Product introduction
硝酸异山梨酯是一种硝酸酯和山梨醇衍生物。它具有血管扩张剂和一氧化氮供体的作用。
Chinese name
1,4:3,6-二脱水-<i>D</i>-山梨糖醇二硝酸酯
English name
[(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
Chinese alias
-
English alias
1,4:3,6-Dianhydro-D-glucitol dinitrate | Coronex | Dinitrate d'isosorbide | Nosim | Sorbidi nitras | Sorquat | SST-101 | Angidil | Isomak R | Dinitrate d'isosorbide [INN-French] | Korodil | BIDIL COMPONENT ISOSORBIDE DINITRATE | (3R,3aS,6S,6aS)-6-(nitroox
CAS number
87-33-2
molecular formula
C6H8N2O8
molecular weight
236.14
Exact mass
BioReagent
PSA
129
Logp
1.3
Safety
  • Health hazard: ERG2024,指南 133(硝酸异山梨酯混合物):· 灭火或稀释水产生的径流可能导致环境污染。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • First aid measures: ERG2024,指南133(异山梨醇二硝酸酯混合物):在加拿大,可能需要为该产品制定应急响应援助计划(ERAP)。请参阅运输单和/或"ERAP"部分。
  • Toxicity summary: 鉴定:硝酸异山梨酯是一种血管扩张剂、抗心绞痛药物。硝酸异山梨酯是一种细小的白色至象牙白色无臭结晶固体。它在水中微溶;在丙酮、氯仿、酒精和乙醚中易溶。适应症:硝酸异山梨酯主要用于缺血性心脏病患者的治疗。它能减少心绞痛发作的次数、持续时间和严重程度。运动耐量增加,对硝酸甘油的需求减少。它对所有类型的心绞痛都有效(稳定型劳力性心绞痛、混合型心绞痛、不稳定型心绞痛和血管痉挛性或变异型心绞痛)。它用于急性心肌梗死中控制缺血性疼痛、降低升高的血压和治疗肺水肿...
  • Regulatory information: 新西兰EPA化学品清单状态:硝酸异山梨酯与少于60%的乳糖、甘露糖、淀粉或磷酸氢钙的混合物:HSNO批准:HSR001303 有控制地批准
  • fire hazard: ERG2024,指南133(硝酸异山梨酯混合物):·灭火后可能重新点燃。
  • interaction: 三种抗心绞痛药物降低了大鼠心脏中去甲肾上腺素的周转率,特别是硝酸异山梨酯(5 mg,口服)和普萘洛尔。
  • Special Reports: SILVIERI LA, DEANGELIS NJ; ANAL PROFILES DRUG SUBST 4 225 (1975). 关于异山梨醇二硝酸酯的综述,包含48篇参考文献,描述其性质、合成、稳定性和降解、代谢、鉴定和分析。
  • Isolation and evacuation: 疏散:ERG2024,指南133(硝酸异山梨酯混合物):·如果罐车、铁路罐车或公路罐车涉及火灾,应在所有方向上隔离800米(1/2英里);同时,考虑在所有方向上初始疏散800米(1/2英里)。
  • DOT ID and Guide: 2907 133
  • FDA Requirements: intended for human use containing certain "coronary vasodilators". The Food and Drug Administraton finds that the following "coronary vasodilators" are extensively regarded by physicians as safe and useful as employed under medical supervision for the management of angina pectoris in some patients. Isosorbide dinitrate is included on this list.
  • Human toxicity extract: /人体暴露研究/ 硝酸异山梨酯过量的不良影响通常是其引起血管扩张、静脉淤血、心输出量减少和低血压的能力所致。这些血流动力学变化可能表现出多种症状,包括颅内压增高,伴有持续性搏动性头痛、意识混乱和中等发热;眩晕;心悸;视觉障碍;恶心和呕吐(可能伴有绞痛甚至血性腹泻);晕厥(尤其是在直立姿势时);气促和呼吸困难,随后呼吸减弱;出汗,皮肤发红或发冷潮湿;房室传导阻滞和心动过缓;麻痹;昏迷;癫痫发作;和死亡。
  • Other safety information: 化学品评估:IMAP评估 - D-山梨醇,1,4:3,6-二脱水-,二硝酸酯:人类健康I级评估
  • Hazard categories and classifications: 特定靶器官毒性 - 单次暴露 - 1类(循环系统、中枢神经系统、胃肠道、肝脏、血液)
  • Antidote and first aid: 增强消除:血液透析和血液灌注无效。婴儿严重高铁血红蛋白症对亚甲蓝治疗无反应可能需要换血。/硝酸盐和亚硝酸盐/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Accidental Release Measures: 泄漏:ERG2024,指南133(异山梨醇二硝酸酯混合物):·防止进入水道、下水道、地下室或密闭区域。
  • Hazardous reactivity and incompatibility: 对纯硝酸异山梨酯及其与乳糖的混合物进行了实验研究,以研究其热稳定性、冲击和摩擦敏感性以及对6号和8号强度雷管的起爆敏感性;这些化合物具有低危险性。
  • Emergency Response Planning Guidelines: 应急响应:ERG2024,指南133(硝酸异山梨酯混合物):·始终远离直接接触火焰的罐车。
  • Exposure Control and Personal Protection: 防护服:ERG2024,指南133(硝酸异山梨酯混合物):·结构消防员防护服提供热保护,但仅提供有限的化学保护。
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Research chemical CAS 87-33-2 1ml

Research chemical CAS 87-33-2 1ml, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

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