WEHI-9625

WEHI-9625

W656131-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX In Vitro WEHI-9625 (0-10 µM; Mcl1 −/− Bax −/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax −/− , but not Bak −/− , cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mcl1 −/− Bax −/− MEFs cells with ABT-737-pretreated Concentration: 0-10 µM Incubation Time: Result: Could prevent cell death. In Vivo WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Bak Bax

WEHI-9625 是一种三环砜类凋亡一级抑制剂，EC 50 为 69 nM。WEHI-9625 可与 VDAC2 结合，增强其抑制小鼠 BAK 驱动的细胞凋亡的能力。WEHI-9625 对人 BAK 和小鼠 BAK 驱动的细胞凋亡完全无活性。

2595314-46-6(DMSO)

C34H27NO5S2

593.71 g/mol

O=C(C(S1)=CC(CS2(=O)=O)=C1C3=C2C=C(C4=CC=CC=C4C(C5=CC=C(OC)C=C5)=O)C=C3)NCC6=CC=C(C)C=C6