Trovafloxacin mesylate is a fluoroquinolone antibiotic and a topoisomerase II α(bacterial Topo IV and DNA gyrase) inhibitor. It blocks the activity of DNA gyrase by forming a stable quinone-DNA complex. Trovafloxacin mesylate is a broad-spectrum antibiotic and shows potent activity against Gram-negative and Gram-positive bacteria.A fluoroquinolone antibiotic and Topo IV inhibitor. Trovafloxacin mesylate is a fluoroquinolone antibiotic and a topoisomerase II α(bacterial Topo IV and DNA gyrase) inhibitor. It blocks the activity of DNA gyrase by forming a stable quinone-DNA complex. Trovafloxacin mesylate is a broad-spectrum antibiotic and shows potent activity against Gram-negative and Gram-positive bacteria. A fluoroquinolone antibiotic and Topo IV inhibitor.