一种阳离子、荧光、碳菁染料，可用作细胞、组织和分离的线粒体中线粒体电位ΔΨm的比率指示剂。线粒体去极化由红色/绿色荧光强度比的降低指示。电位敏感的色移是由于红色荧光J聚集体的浓度依赖性形成。非常适合检测由线粒体呼吸解偶联剂诱导的ΔΨm衰竭。JC-1还已用于多药耐药细胞的功能测定和凋亡相关的线粒体修饰。一种阳离子、荧光、碳菁染料，可用作细胞、组织和分离的线粒体中线粒体电位ΔΨm的比率计指示剂。它用高膜电位橙色标记线粒体，用低膜电位绿色标记线粒体。线粒体去极化由红色/绿色荧光强度比的降低指示。非常适合检测由线粒体呼吸解偶联剂诱导的ΔΨm衰竭。电位敏感的色移是由于红色荧光J聚集体的浓度依赖性形成。JC-1还已用于多药耐药细胞的功能测定和凋亡相关的线粒体修饰。 A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ m in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨ m induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications. A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ m in cells, tissues, and isolated mitochondria. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. Ideal for detection of collapse of ΔΨ m induced by uncouplers of mitochondrial respiration. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.