凋亡素是一种选择性的聚酮化合物，它是由诺卡氏菌引起的凋亡诱导物，主要诱导E1A转化的细胞死亡，并抑制线粒体F | 0 | F | 1 | -ATPase的酶活性。此外，研究表明，在大多数基于细胞的试验中，凋亡肽在溶液中异构化为异凋亡素，但是异凋亡素抑制线粒体F | 0 | F | 1 | --ATPase的能力要低10倍以上有效的。此外，研究表明凋亡素诱导的细胞凋亡可以被BCL-2抑制。 Apoptolidin is a selective polyketide, apoptosis inducer produced by|Nocardiopsis|mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F|0|F|1|-ATPase. In addition, studies suggest that apoptolidin isomerizes in solution into isoapoptolidin within the time frame of most cell-based assays, however isoapoptolidin's ability to inhibit mitochondrial F|0|F|1|--ATPase is over 10 fold less effective. Furthermore, studies show that apoptolidin induced apoptosis can be inhibited by BCL-2.