Zaragozic Acid A是一种角鲨烯合成酶抑制剂和真菌代谢产物，含有新颖的4,6,7-三羟基-2,8-二氧代双环[3.2.1]辛烷-3,4,5-三羧酸核。角鲨烯合酶催化胆固醇合成的第一步，介导法呢基焦磷酸的还原二聚化以产生角鲨烯。Zaragozic Acid A是一种真菌代谢产物，可作为角鲨烯合酶的可逆竞争性抑制剂（体外Ki = 78 pM）。Zaragozic Acid A剂量依赖性地降低HepG2细胞中的胆固醇合成（IC50 = 6 µM）并抑制小鼠的肝胆固醇合成（ED50 = 0.2 mg/kg). Zaragozic Acid A is a squalene synthetase inhibitor and fungal metabolite containing a novel 4,6,7-trihydroxy-2,8-dioxobicyclo[3.2.1]octane-3,4,5-tricarboxylic acid core. Squalene synthase catalyzes the first committed step in cholesterol synthesis, mediating the reductive dimerization of farnesyl pyrophosphate to produce squalene. Zaragozic Acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase (Ki = 78 pM in vitro). Zaragozic Acid A dose-dependently reduces cholesterol synthesis in HepG2 cells (IC50 = 6 μM) and inhibits hepatic cholesterol synthesis in mice (ED50 = 0.2 mg/kg).