ZL-Abu-CONH（CH2）3-吗啉是一种细胞可渗透的二肽基α-酮酰胺，可作为钙蛋白酶1和钙蛋白酶2的有效，高选择性，可逆和活性位点抑制剂（Ki = 140 nM和41 nM，分别）。组织蛋白酶B的弱抑制剂（Ki = 6.9μM）。已显示局部缺血后在中枢神经系统中具有神经保护作用。还可以保护小鼠免受病毒诱导的凋亡性心肌损伤。 Z-L-Abu-CONH(CH2)3-morpholine is a cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of Calpain 1 and Calpain 2 (Ki = 140 nM and 41 nM, respectively). A weak inhibitor of cathepsin B (Ki = 6.9 μM). Has been shown to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.