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名称

Z-Ile-Leu-aldehyde

分子类型

小分子

别名

Z-异亮氨酸-亮氨酸醛

英文名称

Z-Ile-Leu-aldehyde

货号

Z648092-5mg

包装规格

5mg

浓度

≥96%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch. In Vitro Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays. Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRsup> Cell Line: CD4 + T cells from C57BL/6 mice. Concentration: 25 μM. Incubation Time: 24, 48, 72 hours. Result: DownregulateD RORt and IL-17 mRNA expression. Cell Viability Assaysup> Cell Line: MOPC315.BM cells. Concentration: 0, 12, 15 μM. Incubation Time: 24-48 h hours. Result: Reduced viability and induced apoptosis in MOPC315.BM cells In Vivo Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MOPC315.BM mouse model. Dosage: 10 mg/kg. Administration: Intraperitoneally either for 14 days. Result: Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice. Form:Solid

生化机理

Z-Ile-Leu-aldehyde（Z-IL-CHO）是γ-分泌酶和notch的一种强效竞争性肽醛抑制剂。

CAS号

161710-10-7

分子式

C20H30N2O4

分子量

362.46 g/mol

PubChem编号

44366908

Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C=O)NC(=O)OCC1=CC=CC=C1

IIUPAC Name

benzyl N-[(2S,3S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

INCHI

1S/C20H30N2O4/c1-5-15(4)18(19(24)21-17(12-23)11-14(2)3)22-20(25)26-13-16-9-7-6-8-10-16/h6-10,12,14-15,17-18H,5,11,13H2,1-4H3,(H,21,24)(H,22,25)/t15-,17-,18-/m0/s1

InChi Key

WJQLUFQGNVGLKR-SZMVWBNQSA-N

Smiles

CCC(C)C(C(=O)NC(CC(C)C)C=O)NC(=O)OCC1=CC=CC=C1

PubChem CID

44366908

MeSH Entry Terms

benzyloxycarbonyl-isoleucyl-leucinal;GSI-XII cpd;Z-IL-CHO;Z-Ile-Leu-CHO

溶解性

DMSO : ≥ 41 mg/mL (113.12 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

362.221 Da

单同位素质量Monoisotopic Mass

362.221 Da

拓扑极表面积Topological Polar Surface Area

84.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

447.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.800

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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