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Product introduction

ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K i s of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase , respectively. In Vivo ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis . ZD-0892 can reverse advanced pulmonary vascular disease produced in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.7 nM (Human neutrophil elastase), 200 nM (Human neutrophil elastase)

Specs ⸢ View details ⸥

Chinese name

ZD-0892

English name

ZD-0892

Chinese alias

English alias

(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid ((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | HY-19254 | L-Prolinamide, N-(4-methoxybenzoyl)-L-valyl-N-((1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl)- | D

CAS number

171964-73-1

molecular formula

C24H32F3N3O5

molecular weight

499.52 g/mol

Exact mass

≥95%

PSA

105.000 Å²

Logp

4.200

Technical Documents

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