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Product details

名称

ZM223 hydrochloride

别名

ZM223盐酸盐

英文名称

ZM223 hydrochloride

货号

Z661700-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme ( NAE ) inhibitor with excellent anticancer activity. IC50& Target:NEDD8 activating enzyme (NAE) In Vitro:ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC 50 s of 100 and 122 nM, respectively. ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the U Biological Activity:ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme ( NAE ) inhibitor with excellent anticancer activity.

分子式

C23H18ClF3N4O2S2

分子量

538.99 g/mol

Smiles

O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2.[H]Cl

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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