Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases . Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus , Streptococcus pyogenes and S.pneumonia . Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) In Vitro Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC 90 : 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC 90 : 0.03 mg/L). Against quinolone-resistant S. pneumoniae , zabofloxacin (MIC 90 : 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Topoisomerase I Topoisomerase II Quinolone