视黄醇结合蛋白(RBP4) 来源于人血浆

np001023-25μg

25μg

BioReagent

≥95%(SDS-PAGE)

视黄醇结合蛋白 4（RBP4）被认为是连接肥胖与胰岛素抵抗及 2 型糖尿病的关键物质。健康人血浆中视黄醇结合蛋白 4 的浓度约为 40 毫克 / 升（mg/L），而糖耐量异常者和 2 型糖尿病患者的该蛋白水平会更高。孕妇（尤其是妊娠期糖尿病孕妇）体内的视黄醇结合蛋白 4 水平也会升高。此外，心血管疾病患者的视黄醇结合蛋白 4 水平同样呈上升趋势 —— 这是因为该蛋白水平与含载脂蛋白 B（APO B）的脂蛋白（包括低密度脂蛋白 LDL、极低密度脂蛋白 VLDL 以及小而密低密度脂蛋白）水平存在相关性。 本产品由血浆制备而成，经美国食品药品监督管理局（FDA）要求的检测证实，所用血浆对乙型肝炎表面抗原（HBsAg）、丙型肝炎抗体（抗 - HCV）、乙型肝炎核心抗体（抗 - HBc）无反应，且人免疫缺陷病毒 1 型和 2 型抗体（抗 - HIV 1&2）检测结果为阴性。 阿拉丁（Aladdin）产品均为实验室试剂，不得用于人体给药或任何药物用途。仅用于研究或进一步生产使用。 Retinol Binding Protein 4(RBP4) is thought to link obesity with insulin resistance and Type 2 Diabetes. Present in plasma of healthy individuals at a level of approximately 40 mg/L, RBP4 levels are higher in individuals with impaired glucose tolerance and Type 2 Diabetes. RBP4 levels are increased in pregnant women, especially those with gestational diabetes. Increased levels of RBP4 levels are also seen in individuals with cardiovascular disease, as RBP4 levels appear to correlate with levels of APO B-containing lipoproteins-- LDL, VLDL, and small dense LDL. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS. Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47. Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner. Ligand for immunoglobulin-like cell surface receptor SIRPA. Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA. Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging.

天然

21 kDa

人(Human)