纤溶酶 来源于人血浆

np001029-50μg

50μg

天然

≥90%(SDS-PAGE)

纤溶酶在纤维蛋白溶解、纤维蛋白原溶解以及补体级联反应中发挥作用。这种蛋白酶是通过使用链激酶激活人血浆纤溶酶原而制备的。 消光系数：1.71 所用血浆经 FDA 要求的检测显示，乙型肝炎表面抗原（HBsAg）、抗丙型肝炎病毒（抗 - HCV）、抗乙型肝炎核心抗体（抗 - HBc）均为阴性，且抗人类免疫缺陷病毒 1 型和 2 型（抗 - HIV 1 & 2）也为阴性。 Plasmin functions in fibrinolysis, fibrinogenolysis, as well as in the complement cascade. This protease has been prepared by using streptokinase to activate human plasma plasminogen. Extinction Coefficient: 1.71 Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells2 PublicationsAngiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.1 Publication(Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete. The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut. (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue.1 Publication(Microbial infection) Interacts with dengue virus type 2 particles. Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes.

≥15 U/mg protein

天然

81 kDa

人(Human)