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名称

免疫球蛋白M(IgM),普通人血浆

货号

np001055-250μg

包装规格

250μg

浓度

≥95%(SDS-PAGE)

产品介绍

IgM在正常血浆中的浓度为1.2至4.0mg/ml。它是免疫反应过程中产生的第一个免疫球蛋白，是新生儿的第一个抗体，参与自身免疫性疾病的发病机制。IgM水平降低与Wiskott-Aldrich综合征有关。由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。产品引用： Herati RS, et al. Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults. J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29. Anquetil F, et al. IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies. J Immunol. 2015 Apr 15;194(8):3664-74. doi: 10.4049/jimmunol.1402334. Epub 2015 Mar 13. IgM is found in normal plasma at a concentration of 1.2 to 4.0 mg/ml. It is the first immunoglobulin produced during the immune response, the first antibody in neonates, and is involved in pathogenesis of autoimmune diseases. A diminished level of IgM is associated with Wiskott-Aldrich syndrome. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Product Citations: Herati RS, et al. Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults. J Immunol. 2014 Oct 1;193(7):3528-37. doi: 10.4049/jimmunol.1302503. Epub 2014 Aug 29. Anquetil F, et al. IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies. J Immunol. 2015 Apr 15;194(8):3664-74. doi: 10.4049/jimmunol.1402334. Epub 2015 Mar 13.

预测分子量

950000

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「No Dangerous Attributes」

「No upstream and downstream information yet」

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