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名称

免疫球蛋白M(IgM),人骨髓瘤血浆

货号

np001056-250μg

包装规格

250μg

浓度

≥95%(SDS-PAGE)

产品介绍

IgM在正常血浆中的浓度为1.2至4.0mg/ml。它是免疫反应过程中产生的第一个免疫球蛋白，是新生儿的第一个抗体，参与自身免疫性疾病的发病机制。IgM水平降低与Wiskott-Aldrich综合征有关。由骨髓瘤血浆制备，经美国食品药品监督管理局要求的测试显示，骨髓瘤血浆对HBsAg、抗HCV、抗HBc无反应，对抗HIV 1和2呈阴性。产品引用： Laurent L, et al. IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies. Ann Rheum Dis. 2015 Jul;74(7):1425-31. doi: 10.1136/annrheumdis-2013-204543. Epub 2014 Mar 11. IgM is found in normal plasma at a concentration of 1.2 to 4.0 mg/ml. It is the first immunoglobulin produced during the immune response, the first antibody in neonates, and is involved in pathogenesis of autoimmune diseases. A diminished level of IgM is associated with Wiskott-Aldrich syndrome. Prepared from myeloma plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Product Citation: Laurent L, et al. IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies. Ann Rheum Dis. 2015 Jul;74(7):1425-31. doi: 10.1136/annrheumdis-2013-204543. Epub 2014 Mar 11.

预测分子量

970,000 Da

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「No Dangerous Attributes」

「No upstream and downstream information yet」

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