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名称

免疫球蛋白G4(IgG4),普通人血浆

货号

np001057-25μg

包装规格

25μg

浓度

≥95%(SDS-PAGE)

产品介绍

IgG4抗体将主导血吸虫病、淋巴丝虫病和过敏原免疫治疗后患者的IgG反应。与其他IgG亚类不同，IgG4不激活补体。IgA-IgG4联合缺乏与复发性化脓性感染有关。由人血浆制备，经美国食品药品监督管理局要求的测试表明，人血浆对HBsAg、抗HCV、抗HBc无反应，对抗HIV 1和2呈阴性。产品引用： Devaux JJ, Miura Y, Fukami Y, Inoue T, et al. Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy. Neurology. 2016 Mar 1;86(9):800-7. doi: 10.1212/WNL.0000000000002418. Epub 2016 Feb 3. IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies. Bhat NM, Kshirsagar MA, Bieber MM, and Teng NNH. Immunol Invest. 2015;44(4):400-10. doi: 10.3109/ 08820139.2015.1015682. Swisher JFA, et al. IgG4 can induce an M2-like phenotype in human monocyte-derived macrophages through FcγRI. MAbs. 2014;6(6):1377-84. doi: 10.4161/ 19420862.2014.975657. IgG4 antibodies will dominate the IgG response in schistosomiasis, lymphatic filariasis, and in patients after allergen immunotherapy. Unlike the other IgG subclasses, IgG4 does not activate complement. A combined IgA-IgG4 deficiency has been associated with recurrent pyogenic infections. Prepared from human plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Product Citations: Devaux JJ, Miura Y, Fukami Y, Inoue T, et al. Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy. Neurology. 2016 Mar 1;86(9):800-7. doi: 10.1212/WNL.0000000000002418. Epub 2016 Feb 3. IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies. Bhat NM, Kshirsagar MA, Bieber MM, and Teng NNH. Immunol Invest. 2015;44(4):400-10. doi: 10.3109/ 08820139.2015.1015682. Swisher JFA, et al. IgG4 can induce an M2-like phenotype in human monocyte-derived macrophages through FcγRI. MAbs. 2014;6(6):1377-84. doi: 10.4161/ 19420862.2014.975657.

预测分子量

146,000Da

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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