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名称

免疫球蛋白G3(IgG3),普通人血浆

货号

np001059-250μg

包装规格

250μg

浓度

≥95%(SDS-PAGE)

产品介绍

与IgG1一样，IgG3激活补体并对fc受体具有亲和力；因此IgG1和IgG3是IgG亚类中更有效的。IgG3缺乏症与Wiscott-Aldrich病、系统性红斑狼疮、青少年糖尿病和牙周感染有关。IgG抗病毒抗体仅限于IgG亚类1和3，IgG3抗体是第一个出现在感染反应中的抗体。由经美国食品药品监督管理局要求的测试显示对HBsAg、抗-HCV、抗-HBc无反应且对抗-HIV 1和2呈阴性的血浆制备。产品引用： IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies. Bhat NM, Kshirsagar MA, Bieber MM, and Teng NNH. Immunol Invest. 2015;44(4):400-10. doi: 10.3109/ 08820139.2015.1015682. Plomp R, et al. Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3). Mol Cell Proteomics. 2015 May;14(5):1373-84. doi: 10.1074/ mcp.M114.047381. Epub 2015 Mar 10. Like IgG1, IgG3 activates complement and has an affinity for fc receptors; thus IgG1 and IgG3 are the more effective of the IgG subclasses. An IgG3 deficiency is associated with Wiscott-Aldrich disease, systemic lupus erythematosus, juvenile diabetes mellitus, and peridontal infections. IgG anti-viral antibodies are restricted to IgG subclasses 1 and 3, with IgG3 antibodies being the first to appear in response to infection. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Product Citations: IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies. Bhat NM, Kshirsagar MA, Bieber MM, and Teng NNH. Immunol Invest. 2015;44(4):400-10. doi: 10.3109/ 08820139.2015.1015682. Plomp R, et al. Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3). Mol Cell Proteomics. 2015 May;14(5):1373-84. doi: 10.1074/ mcp.M114.047381. Epub 2015 Mar 10.

预测分子量

170,000Da

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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