结合珠蛋白 来源于人血浆

触珠蛋白 | 血红素结合蛋白 | 血红蛋白结合蛋白

binding peptide | BP | haptoglobin alpha(1S)-beta | haptoglobin alpha(2FS)-beta | Haptoglobin | haptoglobin, alpha polypeptide | haptoglobin, beta polypeptide | HP | HP-1 | hp2-alpha | HP2ALPHA2 | HPA1S | MGC111141 | zonulin

np001092-250μg

250μg

BioReagent

≥95%(SDS-PAGE)

人血浆中发现的一种急性期血浆蛋白，每100毫升100-300毫克。它能结合血红蛋白，从而防止铁通过肾脏流失。人类的触珠蛋白具有多态性，有三种主要表型：Hp 1-1、Hp 2-1和Hp 2-2。虽然表型分布在种族和地理位置之间可能存在很大差异，但Hp 2-1表型是人类中最常见的表型。结合珠蛋白的血浆浓度在Hp 1-1患者中最高，在Hp 2-1患者中居中，在Hp 2-2患者中最低。Hp 1-1在结合血红蛋白方面最有效，Hp 2-2最无效。这种功能差异可能与癫痫发作的频率和严重程度有关，因为研究人员发现复发性癫痫发作与Hp 2-2表型之间存在相关性。 An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

天然

Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

<2.0 EU/mg

人(Human)