铜蓝蛋白 来源于人血浆

CERU_HUMAN | Ceruloplasmin | CP | CP 2 | CP2 | Ferroxidase | AB073614

np001106-250μg

250μg

生物活性

≥95%(SDS-PAGE)

An acute-phase reactant. Increased levels are associated with normal pregnancy, rheumatoid arthritis, and cirrhosis. Decreased levels are associated with hepatolenticular degeneration (Wilson's Disease). An elevated level of Cp is found in patients with progressive tumors. Additionally, as Cp is a prooxidant, an elevated level is a sign of cardiovascular disease. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Handling: Following reconstitution, store at 4℃. Avoid freeze-thaw cycles, as this will contribute to protein breakdown. Exposure to sodium (in the form of sodium chloride, sodium phosphate, sodium azide, as well as other sodium containing reagents) should be avoided, as ceruloplasmin may precipitate under these conditions. Buffers that ceruloplasmin is exposed to should bepH-adjusted with potassium hydroxide.

Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu+ oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis.

天然

132 kDa

人(Human)