钙蛋白酶-1,人类红细胞

np001116-25μg

25μg

≥95%(SDS-PAGE)

天然人钙蛋白酶-1（u-Calpain）CAPN1，直接来自制造商的人红细胞。散装数量。可用。 钙蛋白酶-1（μ-Calpain）是一种钙激活的中性半胱氨酸蛋白酶。它是催化80 kDa亚基和30 kDa亚单位的异二聚体，在体外需要50μM Ca2+才能达到半最大活性。它参与了细胞分裂、信号转导和长期增强等事件。钙蛋白酶也被认为在与代谢改变和钙稳态改变相关的各种病理过程中发挥作用。 一个单位是指在25°C下，使用钙蛋白酶活性测定试剂盒（荧光）每分钟水解一ρmol Suc LLVY AMC的酶量 Native Human Calpain-1 (u-Calpain) CAPN1, Human Erythrocyte direct from the manufacturer. Bulk qty. available. Calpain-1 (μ-Calpain) is a calcium activated neutral cysteine protease. It is a heterodimer of a Catalytic 80 kDa subunit and a 30 kDa subunit, which requires 50 μM Ca2+ for half-maximal activity in vitro. Its participation in events such as cell division, signal transduction, and long term potentiation has been suggested. Calpains have also been proposed to play a role in various pathological processes associated with altered metabolism and altered calcium homeostasis. One unit is defined as the amount of enzyme that will hydrolyze one ρmol Suc-LLVY-AMC per minute at 25°C using the Calpain Activity Assay Kit, Fluorogenic Ref: Vilei, E.E. et al. 1997. Journal of Biological Chemistry. 272. 41

110,000 Daltons Catalytic Subunit=80,000 Daltons Regulatory Subunit=30,000 Daltons