天青杀素,人中性粒细胞(阳离子蛋白37)

np001123-25μg

25μg

≥95%(SDS-PAGE)

MW: 37,000** **Azurocidin高度糖基化，这导致SDS-PAGE显示蛋白质的分子量低于37kDa。 天青酸蛋白基因位于19号染色体的短臂上，与蛋白酶3和弹性蛋白酶基因在一个簇中。这三种蛋白质都是丝氨酸蛋白酶同源物；然而，天青酸缺乏酶活性。天青酸的重要性在于其作为多功能炎症介质的作用。它具有抗菌活性，能结合内毒素，对单核细胞具有趋化性。 MW: 37,000** **Azurocidin is highly glycosylated, which causes the protein to show a lower molecular weight by SDS-PAGE than that stated of 37kDa. The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin, however, lacks enzymatic activity. The importance of azurocidin is its role as a multifunctional inflammatory mediator. It has antimicrobial activity, binds endotoxin and is chemotactic for monocytes. Product Citation: Zimmer M, Medcalf RL, Fink TM, Mattman C, Lichter P, and Jenne DE. 1992. Proc. Natl. Acad. Sci. USA 89, 8215. Pereira HA. 1995. J Leukoc Biol. 57, 805. O'Flynn, J., K. O. Dixon, Faber Krol, M. R. Daha, and C. van Kooten. "Myeloperoxidase Directs Properdin-Mediated Complement Activation." Journal of Innate Immunity (2013). Brandt K, Grunler J, Brismar K, Wang J Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts. Growth Horm IGF Res. 2015 Feb;25(1):34-40. doi: 10.1016/j.ghir.2014.11.001. Epub 2014 Nov 8.

37000