载脂蛋白E 来源于人血浆

np001130-10μg

10μg

生物活性

≥95%(SDS-PAGE)

载脂蛋白E作为低密度受体的配体，并参与胆固醇和其他脂质的运输和再分布。其他功能包括免疫调节和细胞生长调节和分化。Apo E被认为参与组织修复，因为在外周神经损伤和再生部位发现了数量增加的蛋白质。一种突变形式与家族性III型高脂蛋白血症有关。正常血浆中载脂蛋白E的浓度为每100毫升5毫克。 阿尔茨海默病研究的研究人员来源。 消光系数:1.31 由新鲜、未冷冻的血浆制备， 所用血浆经 FDA 要求的检测显示，乙型肝炎表面抗原（HBsAg）、抗丙型肝炎病毒（抗 - HCV）、抗乙型肝炎核心抗体（抗 - HBc）均为阴性，且抗人类免疫缺陷病毒 1 型和 2 型（抗 - HIV 1 & 2）也为阴性。 阿拉丁产品是实验室试剂，不得用于人类或用于任何药物目的。仅供研究使用。 Apolipoprotein E serves as a ligand for low density receptors and participates in the transport and redistribution of cholesterol and other lipids. Other functions include immunoregulation and cell growth modulation and differentiation. Apo E is thought to be involved in tissue repair as increased amounts of the protein are found at sites of peripheral nerve injury and regeneration. A mutant form is associated with familial type III hyperlipoproteinemia. The concentration of Apo E in normal plasma is 5 mg per 100 ml. Researchers' source for Alzheimer's Disease Research. Extinction Coefficient: 1.31 Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Post-translational: Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 is a minor glycosylation site compared to Ser-308. Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold). Phosphorylation sites are present in the extracelllular medium.

天然

34 kDa

人(Human)