α2-巨球蛋白 来源于人血浆

α2巨球蛋白

A2M | alpha 2Macroglobulin | alpha 2-Macroglobulin | alpha-2-M | alpha-2-macroglobulin | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 | CPAMD5 | DKFZp779B086 | FWP007 | S863-7 | Macroglobulin Alpha-2 | A2MD

np001158-250μg

250μg

BioReagent

≥95%(SDS-PAGE)

Purified Native Human Alpha 2 Macroglobulin, Human Plasma A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

天然

725 kDa

人(Human)