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Product details

名称

Recombinant Human Azurocidin/CAP37/HBP Protein

别名

天青杀素(AZU)重组蛋白

英文别名

货号

rp143093-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

生化机理

功能这是一种来源于中性粒细胞颗粒的抗菌、单核细胞和成纤维细胞特异性趋化糖蛋白。与肝素结合。其细胞毒性作用仅限于多种革兰氏阴性细菌；这种特异性可能是由于其非常基本的 N 端半部分对革兰氏阴性细菌外包膜特有的带负电荷的脂多糖具有很强的亲和力。它可能在第二波炎症中起到介导单核细胞招募的作用。对革兰氏阴性细菌铜绿假单胞菌具有抗菌活性，但这种活性会受到铜绿假单胞菌 LPS 的抑制。单独使用时，它对革兰氏阴性菌 A.actinomycetemcomitans ATCC 29532、A.actinomycetemcomitans NCTC 9709、A.actinomycetemcomitans ATCC 29532、A.actinomycetemcomitans NCTC 9709 和 A.actinomycetemcomitans ATCC 29532 没有抗菌活性。actinomycetemcomitans FDC-Y4、H.aphrophilus ATCC 13252、E.corrodens ATCC 23834、C.sputigena ATCC 33123、Capnocytophaga sp ATCC 33124、Capnocytophaga sp ATCC 27872 或 E.coli ML-35。与弹性蛋白酶或凝血酶 G 协同作用时，对 C.sputigena ATCC 33123 具有抗菌活性。

生物活性

Measured by its ability to enhance LPS-induced TNF-alpha secretion from human monocytes. The ED50 for this effect is 1.20-12.0 µg/mL.

来源

重组表达

预测分子量

26 kDa

蛋白标签

C-10His

SDS-PAGE

37 kDa, under reducing conditions; 37 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: P20160 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

27-250 aa

序列

IVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPHHHHHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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