Recombinant Human CCL18 Protein

重组人CCL18蛋白

Human Macrophage Inflammatory Protein-4, Alternative macrophage activation-associated CC chemokine 1 | AMAC-1 | AMAC1 | CC chemokine ligand 18 | AMAC-1Small-inducible cytokine A18 | CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulat

rp143731-50μg

50μg

无载体

≥96%(SDS-PAGE&HPLC)

＞96%(SDS-PAGE,HPLC)

Human CCL18 is encoded by the CCL18 gene located on the chromosome 17. As also named MIP-4, it shares 61 % sequence identity to human MIP-1α. CCL18 is mainly expressed by lung and some lymphoid tissues like lymph nodes express CCL18 at low level. It is chemotactic for both activated (CD3+) T cells and nonactivated (CD14-) lymphocytes, but not for monocytes or granulocytes. Involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 plays a role in both humoral and cell mediated immunity responses. Recombinant Human MIP-4/CCL18 is a 7.9kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Purity >96% SDS-PAGE Function Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 1.0-10 ng/ml.

重组表达

7.9kDa

No tag

9.5 kDa, under reducing conditions; 12.0 kDa, under non-reducing conditions.

E. coli Accession #: P55774 | E. coli

<0.1 EU/μg

人(Human)

22-89aa

QVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICA DPNKKWVQKYISDLKLNA

Yes