Recombinant Human CD229/SLAMF3 Protein

重组人CD229/SLAMF3蛋白 | 重组人CD229分子蛋白 | 重组人淋巴细胞抗原9蛋白

Cell surface molecule Ly-9 | Lymphocyte antigen 9 | Signaling lymphocytic activation molecule 3 | SLAM family member 3 | SLAMF3 | SLAM Family Member 3 | CD229 antigen | CD229 | cell-surface molecule Ly-9 | hly9 | Ly9 | lymphocyte antigen 9 | Cell surface

rp143892-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells. May negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells.

Measured by its ability to bind biotinylated Recombinant Human CD229/SLAMF3 in a functional ELISA.

46.1 kDa

C-10His

71-77 kDa under reducing conditions.

HEK293 Accession #: Q9HBG7 | HEK293

<0.1 EU/μg

人(Human)

48-454 aa

KDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKSYLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVTMKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDLPYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRDTEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGPYHAYVCSEASSVTSMTHVTLLIYRRLRKPKITWSLRHSEDGICRISLTCSVEDGGNTVMYTWTPLQKEAVVSQGESHLNVSWRSSENHPNLTCTASNPVSRSSHQFLSENICSGPERNTKHHHHHHHHHH

Yes

Yes