Recombinant Human CD6 Protein

CD6分子(CD6)重组蛋白

T12 | TP120 | CD6 antigen | FLJ44171 | CD6 molecule | CD6 | T12 | Tp120 | T-cell differentiation antigen CD6

rp144066-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.

Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When 5×10^4 cells/well are added to Recombinant Human CD6 Protein (rp144066) coated plates (2 μg/mL and 100 μL/well) in the presence of 10 μg/mL PHA, approximately > 50% cells will adhere specifically after 60 minutes at 37℃.

重组表达

41 kDa

C-His

65 - 90 kDa, under reducing conditions; 65 - 90 kDa, under non-reducing conditions

HEK293 Accession #: P30203 | HEK293

<0.1 EU/μg

人(Human)

18-398 aa

HPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESREHHHHHH

Yes

Yes