Recombinant Human Cardiotrophin-1 Protein

重组人CT-1蛋白 | 重组人心肌营养素1蛋白 | 重组人心肌营养素-1蛋白

cardiophin 1 | Cardiophin1 | cardiotrophin 1 | Cardiotrophin1 | CardiotrophinI | Cardiotrophin-1 | CT-1 | CT1 | CT 1 | CTF1 | CTF 1 | CTF1_HUMAN | CT-1

rp144781-50μg

50μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE)

Purity >95% SDS-PAGE Function Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Background Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross-species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has been implicated in the receptor complex.

Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is typically less than 10 ng/mL.

重组表达

21.2 kDa

No tag

27.2 kDa, under reducing conditions; 27.2 kDa, under non-reducing conditions.

HEK293 Accession #: Q16619 | HEK293

<1.0 EU/μg

人(Human)

2-201 aa

GPSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA

Yes

Yes