Recombinant Human DKK3 Protein

重组人DKK3蛋白

dickkopf (Xenopus laevis) homolog 3 | dickkopf 3 | dickkopf homolog 3 (Xenopus laevis) | Dickkopf-3 | dickkopf-related protein 3 | Dkk3 | Dkk-3 | hDkk-3 | regulated in glioma | REIC | REICdkk-3 | RIG | RIG-like 5-6 | RIG-like 7-1 | Dickkopf-3 | Dkk-3 | hD

rp145156-10μg

10μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE)

Purity >95% SDS-PAGE. Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Post-translational N- and O-glycosylated.

Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is 3-12 µg/mL.

重组表达

37 kDa

C-His

45 - 65 kDa, under reducing conditions; 45 - 65 kDa, under non-reducing conditions.

HEK293 Accession #: Q9UBP4 | HEK293

<0.1 EU/μg

人(Human)

22-350 aa

APAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI

Yes