Recombinant Human Ephrin-A1 Protein

肝配蛋白A1(EFNA1)重组蛋白

EPH-related receptor tyrosine kinase ligand 1 | Immediate early response protein B61 | LERK-1 | TNF alpha-induced protein 4 | Tumor necrosis factor alpha-induced protein 4 | ECKLG | EFL 1 | EFL1 | EFNA 1 | Efna1 | EFNA1_HUMAN | EPH related receptor tyrosi

rp145628-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Ephrin-A1 Protein (rp145628) at 2.0 μg/mL can bind Human EphA1 with the ED50 is 21.1 ng/mL.

重组表达

22 kDa

C-His

25 kDa, under reducing conditions; 25 kDa, under non-reducing conditions.

HEK293 Accession #: P20827 | HEK293

<0.1 EU/μg

人(Human)

19-182 aa

DRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSHHHHHH

Yes

Yes