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Product details

名称

Recombinant Human FGF19 Protein

别名

成纤维细胞生长因子19(FGF19)活性蛋白 | 重组人 FGF19 蛋白

英文别名

FGF19 | FGF-19 | fibroblast growth factor 19 | FGF 19 | FGF15 | FGF19_HUMAN | Fibroblast growth factor 15 | FGF-19

货号

rp145934-25μg

包装规格

25μg

级别

无动物源

浓度

≥98%(SDS-PAGE)

纯度

＞98% SDS-PAGE

产品介绍

Purity ≥ 98% SDS-PAGE. Function Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.

生物活性

FGF19 is a member of the fibroblast growth factor (FGF) family. FGFs are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. In general, FGFs are expressed during embryonic development and in restricted adult tissues. Human FGF-19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites. FGF19-FGFR1 is one of paired transcripts mediating the dialogues between extraembryonic membrane and endometrium. A functional binding ELISA assay was conducted to detect the interaction of Recombinant Human FGF19 Protein (rp145934) and recombinant human FGFR1, the EC50 for this effect is 0.16 μg/mL.

来源

重组表达

预测分子量

27.4 kDa

蛋白标签

N-His

SDS-PAGE

27.7 kDa, under reducing conditions; 27.4 & 54.0 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: O95750 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

4-216 aa

序列

GCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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