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名称

Recombinant Human IL-1 alpha/IL-1F1 Protein

别名

重组人白细胞介素-1α蛋白 | 重组人IL-1 alpha蛋白(Active) | 重组人白细胞介素-1α蛋白 | 重组人IL-1 alpha蛋白(Active)

英文别名

BAF | Hematopoietin-1 | IL1 alpha | IL-1 alpha | IL1 | IL1A | IL-1A | IL1-ALPHA | IL1F1 | IL-1F1 | IL1F1hematopoietin-1 | interleukin 1, alpha | interleukin-1 alpha | LAF | LEM | preinterleukin 1 alpha | pro-interleukin-1-alpha | FAF | Hematopoietin 1 | I

货号

rp147340-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

纯度

≥95% (SDS-PAGE)

产品介绍

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. It possesses metabolic, physiological, hematopoietic activities, and plays one of the central roles in the regulation of the immune responses. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1α is an 18.0kDa protein containing 159 amino acid residues.

生物活性

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 1‑10 ng/mL.

来源

重组表达

预测分子量

18 kDa

蛋白标签

C-His

SDS-PAGE

20 - 25 kDa, under reducing conditions; 20 - 25 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: P01583 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

113-271 aa

序列

SAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQAHHHHHH

无动物源

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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