Recombinant Human IL-17F Protein

重组人白介素17F蛋白 | 重组人 IL-17F 蛋白

Cytokine ML-1 | IL17F | IL-17F | IL-17Finterleukin-17F | interleukin 17F | ML1 | ML-1 | IL17A | CANDF6 | Cytokine ML-1 | IL-17F

rp147435-50μg

50μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE, HPLC)

Purity >95% by SDS-PAGE and HPLC analyses. Function Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.

Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.

重组表达

30.1 kDa

No tag

16.4 kDa, under reducing conditions.

Full length protein

E. coli Accession #: Q96PD4 | E. coli

<1.0 EU/μg

人(Human)

31-163 aa

MRKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ

Yes

Yes