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Product details

名称

Recombinant Human IL-18 Protein

别名

重组人白介素18(IL18)蛋白 | 重组人IL-18蛋白 | 重组人 IL-18 蛋白

英文别名

货号

rp147444-50μg

包装规格

50μg

级别

无动物源

浓度

≥95%(SDS-PAGE&HPLC)

纯度

>95% (SDS-PAGE&SEC-HPLC)

产品介绍

白细胞介素-18 (IL-18)是一种属于IL-1超家族的细胞因子，由巨噬细胞和其他细胞产生。IL-18通过与IL-18受体结合发挥作用，在脂多糖(LPS)等微生物产物感染后，与IL-12一起诱导细胞介导的免疫。经IL-18刺激后，自然杀伤(NK)细胞和某些T细胞释放另一种重要的细胞因子干扰素-γ (IFN-γ)或ⅱ型干扰素，在激活巨噬细胞或其他细胞中起重要作用。该细胞因子与IL12的结合已被证明可以抑制IL-4依赖性IgE和IgG1的产生，并增强B细胞中IgG2a的产生。IL-18结合蛋白(IL18BP)可与该细胞因子发生特异性相互作用，从而负向调控其生物学活性。 Purity Function >95% (SDS-PAGE&SEC-HPLC) Endotoxin level

生物活性

1、Measured by its ability to induce IFN-gamma secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha. The ED50 for this effect is typically 5 - 30 ng/mL. 2、Recombinant Human IL-18 Protein (rp147444) stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line. The ED50 for this effect is typically 0.27 ng/mL.

来源

重组表达

预测分子量

18.2 kDa

蛋白标签

No tag

SDS-PAGE

15.4 kDa, under reducing conditions; 15.4 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: Q14116 | E. coli

内毒素水平

<10 EU/mg

种属

人(Human)

氨基酸

37-193 aa

序列

YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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