Recombinant Human IL-4 Protein

重组人白细胞介素-4 | 重组人IL-4蛋白 | 重组人白介素4蛋白

B cell growth factor 1 | BCDF | B-cell stimulatory factor 1 | BCGF1 | BCGF-1 | binetrakin | BSF1 | BSF-1 | IL4 | IL-4 | IL-4B_cell stimulatory factor 1 | IL4E12 | interleukin 4 | interleukin-4 | Lymphocyte stimulatory factor 1 | MGC79402 | Pitrakinra | B-

rp147593-50μg

50μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

白细胞介素-4 (IL-4)是一种诱导初始辅助T细胞(Th0细胞)向Th2细胞分化的多效性细胞因子，主要由肥大细胞、Th2细胞、嗜酸性粒细胞和嗜碱性粒细胞产生。IL-4是体液免疫和适应性免疫中的关键调节因子，具有许多生物学作用，包括刺激活化的B细胞和t细胞增殖，以及B细胞向浆细胞分化。调节初始CD4+ T细胞向辅助性Th2细胞分化和免疫球蛋白类向IgG1和IgE同型转变。Th2细胞过量产生IL-4与过敏有关。IL-4具有致密的球状褶皱，由3个二硫键稳定。重组白介素-4是一个15kDa的蛋白，由129个氨基酸残基组成。

Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.

Measured in a cell proliferation assay using TF 1 human erythroleukemic cells. The ED50 for this effect is 85-340 pg/mL, corresponding to a specific activity of 2.94 × 106~1.17× 107 units/mg.

重组表达

15 kDa

C-His

20-23 kDa, under reducing conditions

HEK293 Accession #: P05112 | HEK293

<0.1 EU/μg

人(Human)

25-153 aa

HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSSHHHHHH

Yes