Recombinant Human IL-7 Protein

重组人IL-7蛋白 | 重组人白介素7 | 重组人白细胞介素7

IL-7 | Interleukin 7 | IL7 | IL-7 | IL-7interleukin-7 | Lymphopoietin-1 | PBGF | IMD130

rp147631-10μg

10μg

无动物源

≥98%(SDS-PAGE&HPLC)

白细胞介素是由多种细胞产生并作用于多种细胞的一类细胞因子。白细胞介素在传递信息，激活与调节免疫细胞，介导T、B细胞活化、增殖与分化及在炎症反应中起重要作用。 IL-7的靶细胞主要为淋巴细胞，对来自人或小鼠骨髓的B祖细胞、胸腺细胞及外周成熟的T细胞等均有促生长活性。①与干细胞生长因子（SCF）协同能够刺激b前体发生有丝分裂，这一效应可被tgf所抑制；但对B祖细胞（pro-b）的生长没有明显作用。②促进双阴性胸腺细胞的成熟，提供胚胎胸腺细胞发育过程中tcr基因重组的始动信号；但对成熟T细胞无明显作用。③诱导胸腺细胞或外周血淋巴细胞产生LAK细胞活性，其效应细胞主要为CD8+亚群；但IL-7诱导的LAK细胞不具有NK活性。④IL-7能刺激髓样前体细胞和巨核细胞产生集落形成单位和血小板，使机体从环磷酰胺的免疫抑制作用中恢复过来；在较高浓度时，IL-7还能增强巨噬细胞的细胞毒活性，诱导单核细胞分泌细胞因子。 本产品用重组大肠杆菌基因表达生产IL-7，高纯度，高活性，无动物源性污染。

Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.

Measured in a cell proliferation assay using Human PBL cells. The ED50 for this effect is 2×10^6 IU/mg.

重组表达

17.5 kDa

No tag

17.5 kDa

E. coli Accession #: P13232 | E. coli

<10 EU/mg

人(Human)

26-177 aa

MDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH

Yes

Yes