Recombinant Human LAIR1 Protein

白细胞关联免疫球蛋白样受体1(LAIR1)重组蛋白

CD305 | CD305 antigen | CD305leukocyte-associated Ig-like receptor 1 | HLAIR1 | LAIR1 | LAIR-1 | leukocyte-associated immunoglobulin-like receptor 1

rp148162-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Measured by the ability of the immobilized protein to support the adhesion of HeLa human cervical epithelial carcinoma cells. The ED50 for this effect is 0.25-1.0 μg/mL.

重组表达

16.3 kDa

C-His

20 - 34 kDa, under reducing conditions; 20 - 34 kDa, under non-reducing conditions.

HEK293 Accession #: Q6GTX8 | HEK293

<0.1 EU/μg

人(Human)

22-163 aa

QEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRLERDSRSTYNDTEDVSQASPSESEARFRIDSVREGNAGLYRCIYYKPPKWSEQSDYLELLVKESSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHHHHHHH

Yes

Yes