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Product details

名称

Recombinant Human Meprin beta Subunit/MEP1B Protein

别名

重组人Meprin beta Subunit/MEP1B蛋白 | 重组人安眠蛋白1β蛋白 | 重组人Meprin beta Subunit/MEP1B蛋白 | 重组人安眠蛋白1β蛋白

英文别名

货号

rp148698-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

Function Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Cleaves also the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides.

生物活性

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >350 pmol/min/µg, as measured under the described conditions.

来源

重组表达

预测分子量

66 kDa

蛋白标签

C-10His

SDS-PAGE

75 - 95 kDa, under reducing conditions; 75 - 95 & 180 - 220 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: Q16820 | HEK293

内毒素水平

<0.1 EU/μg

种属

人(Human)

氨基酸

21-593 aa & 23-593 aa

序列

LATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSHHHHHHHHHH

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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