Recombinant Human Nectin-3 Protein

重组人类 Nectin-3 蛋白

CDw113 | Nectin cell adhesion molecule 3 | Poliovirus receptor-related protein 3

rp149161-50μg

50μg

无动物源

≥98%(SDS-PAGE)

＞98%(SDS-PAGE)

Purity >98% SDS-PAGE. Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Recombinant Human Nectin-3 Protein is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human PVRL1/NECTIN1 hFc has been identified as an interactor of Nectin-3, thus a binding ELISA assay was conducted to detect the interaction of recombinant human Nectin-3 and recombinant PVRL1/NECTIN1 hFc.

重组表达

39.3 kDa

C-His

71.1 kDa, under reducing conditions; 68.0 kDa, under non-reducing conditions.

HEK293 Accession #: Q9NQS3 | HEK293

<1.0 EU/μg

人(Human)

58-400 aa

GPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDAHHHHHHHHHH

Yes

Yes