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Product details

名称

Recombinant Human Osteoprotegerin Protein

别名

重组人骨保护素蛋白 | 重组人TR11B蛋白 | 重组人骨保护蛋白

英文别名

货号

rp149600-50μg

包装规格

50μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

纯度

＞95%(SDS-PAGE, HPLC)

产品介绍

Purity > 95 % by SDS-PAGE and HPLC analyses. Function Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases.

生物活性

Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).

来源

重组表达

预测分子量

19.7 kDa

蛋白标签

No tag

蛋白长度

Protein fragment

表达系统

E. coli Accession #: O00300 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

22-194 aa

序列

ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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