Recombinant Human ULBP-1 Protein

重组人ULBP-1蛋白 | 重组人UL16结合蛋白1蛋白

ALCAN-beta | N2DL-1 | NKG2D ligand 1 | NKG2DL1 | Retinoic acid early transcript 1I | MULT-1 | ALCAN-beta | N2DL1 | N2DL-1 | NKG2D ligand 1 | NKG2DL | NKG2DL1 | RAET1I | RAET1Ialcan-beta | Retinoic acid early transcript 1I | UL16 binding protein 1 | UL16-b

rp152972-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Function Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Measured by its ability to bind rhNKG2D/Fc Chimera in a functional ELISA.

重组表达

23.1 kDa

C-His

26 - 31 kDa, under reducing conditions; 25 - 29 kDa, under non-reducing conditions.

HEK293 Accession #: Q9BZM6 | HEK293

<0.1 EU/μg

人(Human)

26-215 aa

GWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPHHHHHH

Yes

Yes