Recombinant Mouse IL-1 RI Protein

重组小鼠IL-1 RI蛋白 | 重组小鼠白介素1受体Ⅰ蛋白

Interleukin 1 Receptor I | CD121 antigen-like family member A | CD121a antigen | CD121a | IL-1 RI | IL1R | IL1R1 | IL1RI | IL1RT1 | IL-1RT1 | IL-1RT-1 | Interleukin 1 Receptor 1 | interleukin 1 receptor, type I | interleukin receptor 1 | interleukin-1 rec

rp154122-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Approximately 0.005‑0.015 µg/mL of IL-1 sRI will inhibit 50% of the biological response due to 50 pg/mL of rmIL-1a.

重组表达

38.1kDa

C-His

55-60 kDa under reducing conditions.

HEK293 Accession #: P13504-1 | HEK293

<0.1 EU/μg

小鼠(Mouse)

20-338 aa

LEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKHHHHHH

Yes

Yes