Recombinant Mouse IL-13 Protein

重组小鼠 IL-13 蛋白

Allergic rhinitis | ALRH | BHR 1 | BHR1 | Bronchial hyperresponsiveness 1 (bronchial asthma) | IL 13 | IL-13 | Il13 | IL13_HUMAN | Interleukin 13 | Interleukin-13 | interleukin13 | MGC116786 | MGC116788 | MGC116789 | NC 30 | NC30 | P 600 | P60

rp154139-20μg

20μg

无动物源

≥98%(SDS-PAGE&HPLC)

＞98%(SDS-PAGE,HPLC)

Murine Interleukin-13 (IL-13) is expressed by the IL13 gene located on the chromosome 11 and secreted by many cell types, especially T helper type 2 (Th2) cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human, mouse and rat IL-13 share low homology, but have cross species activity. Recombinant Murine IL-13 is a 12.3kDa protein consisting of 111 amino acid residues Purity ＞98%(SDS-PAGE,HPLC) Function Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses . Positively regulates IL31RA expression in macrophages.

Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <4ng/mL.

重组表达

12.3 kDa

No tag

Full length protein

E. coli Accession #: P20109 | E. coli

<0.01 EU/μg

小鼠(Mouse)

22-131 aa

MPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGF CVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHF ITKLLSYTKQLFRHGPF

Yes

Yes