Recombinant Mouse IL-23 Protein

白介素23(IL23)活性蛋白

IL 23 | IL 23 A | IL 23 subunit alpha | IL 23A | IL 23p19 | IL-23 subunit alpha | IL-23-A | IL-23p19 | IL12B | IL23 | Il23a | IL23P19 | interleukin 12B | Interleukin 23 alpha subunit p19 | Interleukin 23 p19 subunit | interleukin 23 subunit alpha | interl

rp154192-10μg

10μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Measured by its ability to induce IL-17 secretion by mouse splenocytes.The ED50 for this effect is 0.05-0.25 ng/mL.

重组表达

56 kDa

C-His (IL-23a) & No tag (IL-12b)

58-71 kDa, under non-reducing conditions

HEK293 Accession #: P43432,Q9EQ14 | HEK293

<0.1 EU/μg

小鼠(Mouse)

20-196＆23-335 aa

Il12b MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS Il23a LAVPRSSSPDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDSDIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTAHHHHHH

Yes

Yes