Recombinant Mouse IL-36 alpha/IL-1F6 Protein

重组小鼠 IL-36 alpha/IL-1F6 蛋白

FIL1 epsilon | FIL1 | FIL1(EPSILON) | FIL1E | IL-1 epsilon | IL1(EPSILON) | IL1E | IL-1E | IL-1F6 (FIL-1-epsilon) | IL1F6 | IL-1F6 | IL36 alpha | IL-36 alpha | IL36A | interleukin 1 family, member 6 (epsilon) | interleukin 1, epsilon | Interleukin 36, Alp

rp154218-5µg

5μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE)

Purity >95% SDS-PAGE. IL‑36 alpha is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. The receptor for IL‑36 alpha is a combination of IL‑1 Rrp2 (also called IL‑1 RL2 or IL‑1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL‑1 RAcP. IL‑36 alpha, beta and gamma all activate NF‑ kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL‑8. IL‑36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 alpha in skin keratinocytes produces epidermal hyperplasia. IL‑36 alpha is present in kidney tubule epithelia; it is highly overexpressed in tubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis. IL‑36 alpha is induced by inflammation in adipose tissue‑resident alternately activated (M2) macrophages, and reduces adipocyte differentiation.

Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is ＜18 ng/mL.

重组表达

13kDa

N-Met & His

15.5 kDa, under reducing conditions; 15.5 kDa, under non-reducing conditions.

Full length protein

E. coli Accession #: Q9JLA2 | E. coli

<1.0 EU/μg

小鼠(Mouse)

8-160 aa

MAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR

Yes

Yes

Met