Recombinant Mouse Lipocalin-2/NGAL Protein

重组小鼠Lipocalin-2/NGAL蛋白 | 重组小鼠脂质运载蛋白2蛋白

Neutrophil Gelatinase-associated Lipocalin | 24p3 | 25 kDa alpha-2-microglobulin-related subunit of MMP-9 | HNL | LCN2 | lipocalin 2 (oncogene 24p3) | lipocalin 2 | Lipocalin2 | Lipocalin-2 | migration-stimulating factor inhibitor | MSFI | NGAL | Oncogene

rp154312-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in Lipocalin-2. >1.0 µM of Fe(DHBA) can be bound under the described conditions.

22 kDa

C-10His

27 kDa, under reducing conditions; 25 kDa, under non-reducing conditions.

HEK293 Accession #: P11672 | HEK293

<0.1 EU/μg

小鼠(Mouse)

21-200 aa

QDSTQNLIPAPSLLTVPLQPDFRSDQFRGRWYVVGLAGNAVQKKTEGSFTMYSTIYELQENNSYNVTSILVRDQDQGCRYWIRTFVPSSRAGQFTLGNMHRYPQVQSYNVQVATTDYNQFAMVFFRKTSENKQYFKITLYGRTKELSPELKERFTRFAKSLGLKDDNIIFSVPTDQCIDNHHHHHHHHHH

Yes

Yes