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Product details

名称

Recombinant Mouse TGF-beta RII Protein

别名

重组小鼠TGF-beta RII蛋白 | 重组小鼠转化生长因子β受体Ⅱ蛋白 | 重组小鼠TGF-beta RII蛋白 | 重组小鼠转化生长因子β受体Ⅱ蛋白

英文别名

货号

rp154716-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

产品介绍

Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

生物活性

Measured by its ability to inhibit TGF-beta 1 activity on HT2 mouse T cells. The ED50 for this effect is 3-10 ng/mL in the presence of 1 ng/mL of rhTGF-beta 1.

来源

重组表达

预测分子量

45.9 kDa

蛋白标签

C-hFc & His

SDS-PAGE

55 - 65 kDa, under reducing conditions; 100 - 130 & 240 - 260 kDa, under non-reducing conditions.

表达系统

HEK293 Accession #: Q62312-1 | HEK293

内毒素水平

<0.1 EU/μg

种属

小鼠(Mouse)

氨基酸

24-184 aa

序列

RVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNT ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKT EKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTR HVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENV ESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKD SVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFS ELEHPERLSGRSCSQEKIPEDGSLNTTK

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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