Recombinant Rat GM-CSF Protein

重组大鼠粒巨噬细胞集落刺激因子 | 重组大鼠 GM-CSF 蛋白

Colony stimulating factor 2 (granulocyte-macrophage) | Colony-stimulating factor | CSF | CSF2 | CSF-2 | GMCSF | GM-CSF | granulocyte-macrophage colony-stimulating factor | granulocyte-macrophage colony stimulating factor | MGC131935 | MGC138897 | Molgramo

rp155067-50μg

50μg

无动物源

≥98%(SDS-PAGE&HPLC)

＞98% (SDS-PAGE, HPLC)

GM-CSF是一种造血生长因子，刺激中性粒细胞和巨噬细胞的发育，促进早期红系巨核细胞和嗜酸性祖细胞的增殖和发育。它由内皮细胞、单核细胞、成纤维细胞和t淋巴细胞产生。GM-CSF抑制中性粒细胞迁移，增强成熟端细胞的功能活性。GM-CSF也被报道对非造血细胞有功能性作用，并可诱导人内皮细胞迁移和增殖。此外，它还能刺激多种肿瘤细胞系的增殖，包括成骨肉瘤、癌和腺癌细胞系。据报道，GM-CSF没有跨物种的生物学效应。重组鼠GM-CSF是一个14.5kDa的球状蛋白，由127个氨基酸残基组成。 Purity >98% SDS-PAGE. > 98 % by HPLC. Additional sequence information This product is for the mature full length protein. The signal peptide is not included. Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Background GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. GM-CSF has also been reported to have a functional role on non-hematopoietic cells and can induce human endothelial cells to migrate and proliferate. Additionally, it can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. It is reported that GM-CSF has no biological effects across species. Recombinant Rat GM-CSF is a 14.5kDa globular protein consisting of 127 amino acid residues.

Measured in a cell proliferation assay using murine FDC-P1 cells. The ED50 for this effect is typically <0.02 ng/mL.

重组表达

14.5 kDa

No tag

13.7 kDa, under reducing conditions; 13.7 kDa, under non-reducing conditions.

Full length protein

E. coli Accession #: P48750 | E. coli

<0.01 EU/μg

大鼠(Rat)

18-144 aa

APTRSPNPVTRPWKHVDAIKEALSLLNDMRALENEKNEDVDIISNEFSI QRPTCVQTRLKLYKQGLRGNLTKLNGALTMIASHYQTNCPPTPETDCE IEVTTFEDFIKNLKGFLFDIPFDCWKPVQK

Yes

Yes