Recombinant Rat IL-6 Protein

重组大鼠 IL-6 蛋白

B-cell differentiation factor | B-cell stimulatory factor 2 | BSF2 | BSF-2 | CDF | CTL differentiation factor | hybridoma growth factor | MGI-2A | Interleukin BSF 2 | Cytotoxic T cell differentiation factor | Hepatocyte stimulating factor | Hepatocyte sti

rp155124-50μg

50μg

无动物源

≥96%(SDS-PAGE&HPLC)

＞96% (SDS-PAGE, HPLC)

Interleukin-6 (IL-6) is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Rat IL-6 is a 21.7kDa protein containing 187 amino acid residues. Purity >96% SDS-PAGE Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

1. Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.01 ng/mL, corresponding to a specific activity of >1.0 ×108 IU/mg. 2. Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is less than 10 ng/mL.

重组表达

21.7 kDa

No tag

20.9 kDa, under reducing conditions; 19.1 kDa, under non-reducing conditions.

E. coli Accession #: P20607 | E. coli

<0.1 EU/μg

大鼠(Rat)

25-211 aa

FPTSQVRRGDFTEDTTHNRPVYTTSQVGGLITYVLREILEMRKELCNGN SDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKICSGLLEFRFY LEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDSYKIVLPTPTSNAL LMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT

Yes

Yes