Recombinant MPXV A29L Protein

重组猴痘病毒 A29L 蛋白

OPG154 | A29L | IMV surface protein A29L | Monkeypox virus | Monkeypox virus A29L

rp155836-1mg

1mg

无载体

≥95%(SDS-PAGE)

＞95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. A29L is an intracellular mature virus (IMV) surface envelope protein that is homologous to vaccinia virus (VACV) A27 and is widely conserved in the Poxviridae family. The A27L protein (p14) is a multifunctional protein that has been implicated in virus attachment, virus–cell fusion, cell–cell fusion, plaque size, and the formation of enveloped virions. The involvement of A27 in mature virus (IMV) inhibits the assembly of fusion protein A26. After MVs are endocytosed by vesicles, the acidic endocytic environment activates the dissociation of A26 protein from MVs, resulting in fusion of the viral membrane with the vesicle membrane. A27 interacts with the integral membrane protein A17, and then forms a protein complex with A26 through disulfide bond linkage to anchor the A26 protein to mature virus (MV) particles.

重组表达

14.7 kDa

N-His

13.2 kDa, under reducing conditions; 37-46 kDa, under non-reducing conditions

Full length protein

E. coli Accession #: Q77HM6 | E. coli

猴痘病毒(Monkeypox virus)

1-110 aa

MGSSHHHHHHSSGLVPRGSHMDGTLFPGDDDLAIPATEFFSTKAAKNPETKREAIVKAYGDDNEETLKQRLTNLEKKITNITTKFEQIEKCCKHNDEVLFRLENHAETLRAAMISLAKKIDVQTGRRPYE

Yes